The effect of ubiquitination on hematopoietic stem cell differentiation and transformation [electronic resource] / Iannis Aifantis ; Immunology Interest Group.

(CIT): Both during his work with Harald von Boehmer and more recently as an independent investigator, Iannis made seminal contributions to the study of early T cell development. More recently, he became interested in the study of Notch-induced T leukemogenesis. Hematopoietic Stem Cell (HSC) self-renewal and differentiation are regulated by the orchestrated function of evolutionarily conserved signaling pathways (i.e. Notch, Wnt), transcription factors (i.e. c-Myc, Bmi1) and cell cycle regulators (i.e. cyclins, CDK inhibitors). These same pathways could also function as rheostats of stem cell transformation as aberrant signaling strength could turn physiological HSC to cancer initiating cells (or cancer stem cells). Iannis's seminar will focus on the study of the Notch1 signaling pathway and discuss its ability to transform HSC and induce T cell acute lymphoblastic leukemia (T-ALL). He will also discuss the recent identification of the E3 ubiquitin ligase Fbw7 as a regulator of Notch1 activity and a T-ALL tumor suppressor, and present new unpublished data on the generation and characterization of Fbw7 conditional knock-out animals. Iannis has established himself as an incisive researcher and original thinker. He is an engaging speaker and should entertain us with a great talk at the interface of immunology and cancer research The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat. For more information, visit The Immunology Interest Group.

Channel: NIH Video Length: 60m 10s Date Found: Tue, Sep 16 2008 6:53 PM Category: Science Date Produced: View Count: 57