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Prigrizek s TiO2-odločitev je vaša Details
Prigrizek s TiO2-odločitev je vaša
Nanodelci imajo zaradi svojih dimenzij posebne lastnosti, ki omogočajo njihovo uporabo na najrazličnejših področjih. Zaradi vse večje proizvodnje in uporabe, smo jim vse bolj izpostavljeni, o njihovih učinkih na ljudi in okolje pa je znano zelo malo. Nanodelci titanovega dioksida (TiO2) so eni izmed najpogosteje uporabljanih nanodelcev. Zaradi nizke toksičnosti TiO2 se njegova uporaba v nanovelikosti vse bolj uveljavlja v prehranski industriji, kozmetiki, papirni industriji, industriji plastičnih mas, barvil itn. Vendar pa novejše raziskave kažejo, da lahko TiO2 v obliki nanodelcev povzroča poškodbe DNK, vnetja, poškodbe jeter in poškodbe pljuč, ter tako pri izpostavljenih ljudeh povzroči škodljive posledice. Raziskovalci na Oddelku za genetsko toksikologijo in biologijo raka Nacionalnega inštituta za biologijo v Ljubljani se zavedamo te problematike in smo eni izmed maloštevilnih v Sloveniji, ki se ukvarjamo z vprašanjem varnosti nanodelcev. V svojih raziskavah proučujemo toksično delovanje nanodelcev TiO2 v testnem modelu s človeškimi jetrnimi celicami HepG2. Pokazali smo, da izpostavitev celic nanodelcem TiO2 povzroča oksidativni stres, poškodbe DNA in sprožitev apoptoze, kar lahko poveča tveganje za nastanek raka in drugih bolezni. Naši rezultati prestavljajo dobro osnovo za nadaljnje raziskave toksičnosti TiO2 in drugih nanodelcev, kot tudi za razvoj novih eksperimentalnih modelov, ki bodo primerni za raziskave toksikoloških lastnosti nanodelcev.
Channel:
VideoLectures
Video Length:
0s
Date Found:
Fri, Mar 25 2011 11:26 AM
Category:
Educational
Date Produced:
Thu, Mar 24 2011 3:00 AM
View Count:
2
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