Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes [electronic resource] / Andrea Califano.

(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, formation of active complexes with one or more transcriptional co-factors, and protein specific degradation and stabilization processes. We introduce a method for the genome-wide computational inference of post-translational modulators of a transcription factor, which are able to affect the ability of the TF to activate/repress its targets. This information theoretic method, MINDY, directly analyzes the multivariate statistical dependencies between a transcription factor and one or more of its targets, conditional on the presence (or absence) of a candidate modulator gene. For more information, visit

Channel: NIH Video Length: 1m 6s Date Found: Wed, Nov 19 2008 1:03 PM Category: Science Date Produced: View Count: 16